Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1930-8 ABBV-744, a selective inhibitor of the BD2 domains of BET family proteins, is effective against prostate cancer in mouse xenograft models, with lower toxicities than the dual-bromodomain BET inhibitor ABBV-075.

Alarm over China virus, extreme Arctic warming and a volcano on alert

Nature, Published online: 22 January 2020; doi:10.1038/d41586-020-00109-1 The latest science news, in brief.

Redox-switchable carboranes for uranium capture and release

Nature, Published online: 22 January 2020; doi:10.1038/s41586-019-1926-4 Redox-switchable chelation is demonstrated for a carborane cluster molecule, leading to controlled chemical or electrochemical capture and release of uranyl in monophasic or biphasic model solvent systems.

Structure of the transcription coactivator SAGA

Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1933-5 Structural studies on the yeast transcription coactivator complex SAGA (Spt–Ada–Gcn5–acetyltransferase) provide insights into the mechanism of initiation of regulated transcription by this multiprotein complex, which is conserved among eukaryotes.

The night markets of Mellador

Nature, Published online: 22 January 2020; doi:10.1038/d41586-019-03935-0 A taste not to be forgotten.

How the stress of fight or flight turns hair white

Nature, Published online: 22 January 2020; doi:10.1038/d41586-019-03949-8 Signalling from the sympathetic nervous system of mice when subjected to stress leads to the depletion of a stem-cell population in their hair follicles. This discovery sheds light on why stress turns hair prematurely grey.

Podcast: How stress can cause grey hair, and the attitude needed to tackle climate change

Nature, Published online: 22 January 2020; doi:10.1038/d41586-020-00168-4 Hear the latest science news, brought to you by Nick Howe and Benjamin Thompson.

Software searches out reproducibility issues in scientific papers

Nature, Published online: 22 January 2020; doi:10.1038/d41586-020-00104-6 Papers are getting more rigorous, but progress is slower than some researchers would like.

Ancient West African foragers in the context of African population history

Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1929-1 Genome-wide ancestry profiles of four individuals, dating to 8,000 and 3,000 years before present, from the archaeological site of Shum Laka (Cameroon) shed light on the deep population history of sub-Saharan Africa.

Giant virus diversity and host interactions through global metagenomics

Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1957-x Giant virus diversity and host interactions through global metagenomics

Liver fibrosis ‘off switch’ discovered in mice

Researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis. Continue Reading at ScienceDaily.com Click Here.

Novel communication between intestinal microbes and developing immune cells in the thymus

Researchers discover microbes regulate the development of specialized immune cells in the thymus that play a critical role in mucosal tolerance. Continue Reading at ScienceDaily.com Click Here.

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