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In vivo single-molecule analysis reveals COOLAIR RNA structural diversity
Nature, Published online: 17 August 2022; doi:10.1038/s41586-022-05135-9
The structures of single COOLAIR RNA isoforms change in abundance and shape in response to external conditions; structural mutation of these isoforms altered FLC expression and flowering time, consistent with a regulatory role of the COOLAIR structure in FLC transcription.