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Less prostate cancer screening reduces overdiagnosis but may miss aggressive cases

Over the past 15 years, public health authorities have downgraded recommendations for the prostate-specific antigen (PSA) test as a screening tool to reduce the overdiagnosis and overtreatment of men with low-grade prostate cancer. Now, researchers have found that while these efforts have been effective, the incidence of higher-grade disease and metastasis at diagnosis have risen.

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