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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer
Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1930-8
ABBV-744, a selective inhibitor of the BD2 domains of BET family proteins, is effective against prostate cancer in mouse xenograft models, with lower toxicities than the dual-bromodomain BET inhibitor ABBV-075.