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Locally renewing resident synovial macrophages provide a protective barrier for the joint
Nature, Published online: 07 August 2019; doi:10.1038/s41586-019-1471-1
Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.