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Structure and mechanism of the cation–chloride cotransporter NKCC1
Nature, Published online: 31 July 2019; doi:10.1038/s41586-019-1438-2
The cryo-EM structure of the zebrafish cation–chloride cotransporter NKCC1 reveals the domain organization, ion translocation pathway, ion-binding sites and key residues for binding activity, providing insights into the activity of this family of transporter proteins with key roles in physiology.