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m6A enhances the phase separation potential of mRNA
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1374-1
The cytosolic N6-methyladenosine (m6A)-binding proteins YTHDF1, YTHDF2 and YTHDF3 undergo liquid–liquid phase separation in vitro and in cells; this is enhanced by polymethylated mRNAs to form complexes that partition into different cellular phase-separated compartments.