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Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4
Nature, Published online: 13 April 2022; doi:10.1038/s41586-022-04590-8
Cryo-electron microscopy structures of three adhesion G protein-coupled receptors (aGPCRs) complexes provide insight into the tethered activation mechanism of aGPCRs and show the potential for rational design of agonists.