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In the biomaterials industry, electrospinning is a ubiquitous fabrication method used to produce nano- to microscale fibrous meshes that closely resemble native tissue architecture. Alas, the process has traditionally used solvents that not only are environmentally hazardous but also a significant barrier to industrial scale-up, clinical translation, and widespread use. But now, researchers report that they have developed a ‘green electrospinning’ process that addresses those challenges, from managing environmental risks of volatile solvent storage and disposal at large volumes to meeting health and safety standards during both fabrication and implementation.